Making sprite like this

Trying to build an art like this for my games, but only in one layer.
Any ideas??
aND IT’ll be in 3d, so basically i may need it to have, free form deformations in it, as it is
relative to 3d camera.

basically painting like Kim Jung Gi, if you are not familiar with that name,

it is alla prima on traditional painting or more familiar as, direct painting